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朱东亚

        朱东亚男,1956年11月出生,博士,教授,博士生导师。南京医科大学药学学科带头人、南京医科大学药学院院长。2001年获中国药科大学药理学博士学位。2001-2003加拿大卡尔加里大学医学院博士后。近年来的研究方向是血管病发病机制及创新药物研究,主要开展血管病发病的分子病理学研究、药物新靶标发现和创新药物的设计、合成、筛选及临床前评价。主持科技部重大科技专项、国家自然科学基、江苏省自然科学基金重点项目及重大技术创新等10余项科研项目,在SCI收录国际学术刊物发表研究论文30余篇,申请国家发明专利3项。

代表性成果:(表示通讯作者)
1. Zhou L,Li F,Xu HB,Luo CX,Wu HY,Zhu MM,Lu W,Ji X,Zhou QG, Zhu DY*.Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med,2010 ;16(12):1439-43.
2. Zhang J, Huang XY, Ye ML, Luo CX, Wu HY, Zhu DY*.Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A-receptor in modulating anxiety-related behaviors. J Neurosci, 2010 ;30(7):2433-41.
3. Li WL, Cai HH, Wang B, Chen L, Zhou QG, Luo CX, Liu N, Ding XS, Zhu DY*. Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke. J Neurosci Res, 2009;87(1):112-122.
4. Jiang J, Wang W, Sun YJ, Hu M, Li F and Zhu DY*.Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Eur J Pharmacol,2007; 561(1-3):54-62.
5.Luo CX, Zhu XJ, Zhou QG, Wang B, Wang W, Cai HH, Sun YJ, Hu M, Jiang J, Hua Y, Han X, Zhu DY*. Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. J Neurochem, 2007 ;103(5):1872-82.
6.Luo CX, Jiang J, Zhou QG, Zhu XJ, Wang W, Zhang ZJ, Han X, Zhu DY*.Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. J Neurosci Res, 2007 ;85(8):1637-46.
7.Luo CX, Zhu XJ, Zhang AX, Wang W, Yang XM, Liu SH, Han X, Sun J, Zhang SG, Lu Y, Zhu DY*. Blockade of L-type voltage-gated Ca2+channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse. J Neurochem, 2005 ;94(4):1077-86.
8.Zhu DY, Lau L, Liu SH, Wei JS.Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA, 2004 ;101(25):9453-7.
9.Zhu DY, Liu SH, Sun HS, Lu YM. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci, 2003; 23(1):223-229.
10. Zhu DY*,Deng Q,Yao HH,Wang DC,Deng Y,Liu GQ. Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice. Life Sci, 2002; 71(17):1985-96.
11.朱东亚。国家发明专利,专利名称:阻断NR2B信号通路的多肽类似物及其制备方法和药物用途,申请号:2007100250064,专利号公开号CN 101134780A。