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徐涌

         徐涌,男,1976年12月出生,博士,南京医科大学特聘教授,博士生导师。1999年毕业于北京大学生物系获理学学士学位,2004年毕业于美国波士顿大学医学院(BUSM)获得哲学博士学位。2004年10月至2007年8月期间在美国波士顿医学中心从事博士后研究。2007年9月回国在南京医科大学组建实验室,任实验室负责人(Principle Investigator), 主要从事生物大分子的翻译后修饰及表观遗传修饰在心血管疾病中的作用机制研究。近年来先后主持了包括美国心脏病学会基金、国家自然科学基金、江苏省自然科学基金等科研项目。自2003年以来,已经在J Biol ChemNuc Acids ResMol Cell Biol等国际权威学术期刊上发表论文14 篇,累计引用次数超过100次。

代表性成果:(表示通讯作者) 
1. Fang F, Yang Y, Yuan Z, Gao Y, Zhou J, Chen Q, Xu Y*. Myocardin-related transcription factor A mediates oxLDL-induced endothelial injury. Circ Res. 2011; 108: 797-807.
2. Wu XY, Kong XC, Luchsinger L, Smith BD, Xu Y*. Regulating the activity of class II transactivator by post-translational modifications: Exploring the possibilities. Mol Cell Biol, 2009; 29(21): 5639-44.
3. Fang MM, Kong XC, Fang F, Li P, Wu XY, Bai H, Qi XH, Chen Q, Xu Y*. RFXB and its splice variant RFXBSV mediate the antagonism between IFN-γ and TGF-β on COL1A2 transcription in vascular smooth muscle cells. Nucleic Acids Research, 2009; 37(13): 4393-406.
4. Kong XC, Fang MM, Fang F, Li P, Xu Y*. PPARγ enhances IFNγ-mediated transcription and rescues TGFβ antagonism by stimulating CIITA in smooth muscle cells. J Mol Cell Cardiol, 2009; 46(5): 748-57.
5. Kong XC, Fang MM, Li P, Fang F, Xu Y*. HDAC2 deacetylates CIITA and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol, 2009; 46(3): 292-9.
6. Xu Y, Ravid K, Smith BD. Major histocompatibility class II transactivator (CIITA) expression in smooth muscle cells from A2b adenosine receptor (A2bAR-/-) knockout mice: crosstalk between the adenosine and IFN-gamma signaling. J Biol Chem, 2008; 283(21): 14213-20.
7. Xu Y, Harton J, Smith BD.CIITA mediates interferon-gamma repression of collagen transcription b through phosphorylation dependent interactions with co-repressor molecules. J Biol Chem, 2008 ;283(3): 1243-56.
8. Xu Y, Farmer SR, Smith BD. Peroxisome proliferator-activated receptor gamma interacts with CIITA/ RFX5 complex to repress type I collagen gene expression. J Biol Chem, 2007;282(36): 26046-56.
9. Xu Y, McDonald J, Perloff E, Buttice G, Schreiber BM, Smith BD: Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Mol Immunol, 2007 ;44(7): 1709-21.
10. Xu Y, Sengupta PK, Seto E, Smith BD: Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression. J Biol Chem, 2006;281(14): 9260-70.
11. Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD: Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma). J Biol Chem, 2004 ;279(40): 41319-32.